CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

Abstract Background B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 domain is considered as a potent ‘death domain’ while the BH4 domain is required for anti-apoptotic activity. Bcl-2...

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Bibliografiske detaljer

Principais autores:	Yihua Lin, Yiling Zhao, Minggui Chen, Zishuo Li, Qiao Liu, Jian Chen, Yi Ding, Chunyong Ding, Ye Ding, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Jia Zhou, Lijing Wang, Qian-Qian Zhang
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2023-05-01
Serier:	BMC Cancer
Fag:	CYD0281 B-cell lymphoma 2 (Bcl-2) Bcl-2 homology (BH) domains BH4 domain antagonist Apoptosis Angiogenesis
Online adgang:	https://doi.org/10.1186/s12885-023-10974-4
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