Enhancing the bioconversion of phytosterols to 22-hydroxy-23,24- bisnorchol-4-ene-3-one in Mycobacterium neoaurum ZS-15 through genetic modification of kstD1 and wecA

Abstract Background C22 steroidal intermediates, including 22‑hydroxy‑23,24‑bisnorchol‑4‑ene‑3‑one (4‑HBC) and its Δ1‑dehydrogenated derivative 1,4‑HBC serve as key precursors for synthesizing progestational and adrenocortical hormones. However, the accumulation of multiple products coupled with the...

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Autors principals:	Shilun Guo, Mingzhu Song, Zhe Song, Tengwei Liu, Di Zhang, Haoyang Zhang, Xiaoxing Liu, Yujue Wang, Guifu Dai
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-01-01
Col·lecció:	Microbial Cell Factories
Matèries:	Mycobacterium neoaurum KstD WecA 22-hydroxy-23,24-bisnorchol-4-ene-3-one CRISPR technology
Accés en línia:	https://doi.org/10.1186/s12934-025-02921-8
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