Evaluation of the cytotoxicity and antibacterial activity of a synthetic tunicamycin derivative against Mycobacterium avium complex

Two synthetic derivatives of the tunicamycin antibiotic, TunR1 and TunR2, were previously developed that significantly reduced toxicity in eukaryotes but remained potent against Gram positive prokaryotes. TunR2 has been demonstrated to be non-toxic and effective in a zebrafish model of mycobacterial...

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Auteurs principaux:	Maria A. Colombatti Olivieri, Neil P. J. Price, Michael A. Jackson, John P. Bannantine
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2025-05-01
Collection:	Frontiers in Microbiology
Sujets:	tunicamycin Mycobacterium avium complex (MAC) Mycobacterium paratuberculosis (MAP) cytotocixicity minimal inhibition concentration (MIC)
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1604400/full
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