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Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels. Upregulation of ATX expression in obese pati...

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Principais autores: Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhenwen Zhao, Junjie Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-11-01
coleção:Journal of Lipid Research
Assuntos:
glycoprotein 130
autotaxin
adipocyte
insulin sensitivity
obesity
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520338013
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