Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels. Upregulation of ATX expression in obese pati...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhenwen Zhao, Junjie Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2017-11-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	glycoprotein 130 autotaxin adipocyte insulin sensitivity obesity
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0022227520338013
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