ROS-responsive 3D biological scaffold delivers hypoxia-primed extracellular vesicles for targeted modulation of neuroinflammation in intracerebral hemorrhage

Abstract Background Emerging evidence suggests that paracrine mechanisms may underlie the therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (EVs) (hUCMSC-exos) in mitigating neuroinflammation following intracerebral hemorrhage (ICH). Hypoxic preconditio...

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Autori principali:	Aobo Zhang, Dan Qiao, Ziyang Jia, Zhanzhan Zhang, Dongdong Yan, Chengrui Nan, Liqiang Liu, Yunpeng Shi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-10-01
Serie:	Stem Cell Research & Therapy
Soggetti:	3D biological scaffold Hypo-Exos Intracerebral hemorrhage Neuroinflammation miR-146b/COP1
Accesso online:	https://doi.org/10.1186/s13287-025-04691-x
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