The mechanism of activation of monomeric B-Raf V600E
Oncogenic mutations in the serine/threonine kinase B-Raf, particularly the V600E mutation, are frequent in cancer, making it a major drug target. Although much is known about B-Raf’s active and inactive states, questions remain about the mechanism by which the protein changes between these two state...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science (AAAS)
2021-01-01
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| coleção: | Computational and Structural Biotechnology Journal |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2001037021002397 |
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