Massively parallel analysis of human 3′ UTRs reveals that AU-rich element length and registration predict mRNA destabilization

AbstractAU-rich elements (AREs) are 3′ UTR cis-regulatory elements that regulate the stability of mRNAs. Consensus ARE motifs have been determined, but little is known about how differences in 3′ UTR sequences that conform to these motifs affect their function. Here, we use functional annotation of...

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Hlavní autoři:	David A Siegel, Olivier Le Tonqueze, Anne Biton, Noah Zaitlen, David J Erle
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2021-11-01
Edice:	G3: Genes, Genomes, Genetics
On-line přístup:	https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab404
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