PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis

Patients infected by Leishmania braziliensis develop debilitating skin lesions. The role of inhibitory checkpoint receptors (ICRs) that induce T cell exhaustion during this disease is not known. Transcriptional profiling identified increased expression of ICRs including PD-1, PDL-1, PDL-2, TIM-3, an...

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Auteurs principaux:	Renan Garcia de Moura, Luciana Polaco Covre, Carlos Henrique Fantecelle, Vitor Alejandro Torres Gajardo, Carla Baroni Cunha, Lorenzzo Lyrio Stringari, Ashton Trey Belew, Camila Batista Daniel, Sandra Ventorin Von Zeidler, Carlos Eduardo Tadokoro, Herbert Leonel de Matos Guedes, Raphael Lubiana Zanotti, David Mosser, Aloisio Falqueto, Arne N. Akbar, Daniel Claudio Oliveira Gomes
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2021-03-01
Collection:	Frontiers in Immunology
Sujets:	cutaneous leishmaniasis Leishmania braziliensis T cell exhaustion PD-1 inhibitory checkpoint receptors senescent T cells
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.632667/full
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