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Design and Synthesis of Novel β-catenin/BCL9 Protein–Protein Interaction Small Molecule Inhibitors for the Treatment of Colorectal Cancer

Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies. The development of novel targeted drug therapeutics against CRC has been a research hotspot. Among these strategies, disrupting the β-catenin/BCL9 protein–protein interaction (PPI) emerges as a promising approach for th...

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Principais autores: Yuyan Long, Mengfei Wang, Qingwei Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Georg Thieme Verlag KG 2026-06-01
coleção:Pharmaceutical Fronts
Assuntos:
colorectal cancer
protein–protein interaction
β-catenin
BCL9
small-molecule inhibitors
phenylpiperidine derivatives
Acesso em linha:http://www.thieme-connect.de/DOI/DOI?10.1055/a-2834-4404
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