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Organic Selenium induces ferroptosis in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDA) cells reprogram both mitochondrial and lysosomal functions to support growth. At the same time, this causes significant dishomeostasis of free radicals. While this is compensated by the upregulation of detoxification mechanisms, it also represents a potential v...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Roberta Noè, Noemi Inglese, Patrizia Romani, Thauan Serafini, Carlotta Paoli, Beatrice Calciolari, Marco Fantuz, Agata Zamborlin, Nicoletta C. Surdo, Vittoria Spada, Martina Spacci, Sara Volta, Maria Laura Ermini, Giulietta Di Benedetto, Valentina Frusca, Claudio Santi, Konstantinos Lefkimmiatis, Sirio Dupont, Valerio Voliani, Luca Sancineto, Alessandro Carrer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2023-12-01
Schriftenreihe:Redox Biology
Schlagworte:
Pancreatic cancer
Ferroptosis
Selenorganic compounds
Dibenzyl diselenide (DBDS)
Mevalonate pathway (MVP)
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2213231723003634
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