Resistance Mutations to Broadly Neutralizing Antibodies Destabilize Hemagglutinin and Attenuate H1N1 Influenza Virus

Because antigenic drift primarily generates amino-acid changes in the membrane-distal hemagglutinin (HA) head, broadly neutralizing antibodies (bNAbs) are being developed to target conserved epitopes in the membrane-proximal stem. Mutations to HA2 residue A44, a buried residue beneath the central st...

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書誌詳細

主要な著者:	Guohua Yang, Po-Ling Chen, Samuel W. Rovito, Karine Minari, Haley N. Writt, Jennifer DeBeauchamp, Jeri Carol Crumpton, Lisa Kercher, Rebecca M. DuBois, Richard J. Webby, Charles J. Russell
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2025-12-01
シリーズ:	Viruses
主題:	influenza virus hemagglutinin monoclonal antibody neutralization antibody escape viral fusion glycoproteins
オンライン･アクセス:	https://www.mdpi.com/1999-4915/18/1/32
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