Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex

Abstract Emerging evidence suggests that the sterile alpha‐motif (SAM) and histidine‐aspartate (HD) domain‐containing protein 1 (SAMHD1) is implicated in various cancers, including hepatocellular carcinoma (HCC). However, its precise role in tumor cells and the underlying mechanisms remain unclear....

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Principais autores:	Juntang Shao, Wei Wang, Shiyu Li, Guangfa Yin, Lili Han, Xinyu Wang, Meng Cai, Tao Yang, Ying Wang, Wenyan Qu, Yanhong Jiao, Peng Wang, Hanyang Xu, Xu Zhu, Songcheng Ying, Sa Xu, Qiang Sheng, Jian Fang, Tongcui Jiang, Chuansheng Wei, Yujun Shen, Yuxian Shen
格式:	Artigo
語言:	Inglês
出版:	Wiley 2025-02-01
叢編:	Advanced Science
主題:	cell cycle cohesin complex HCC SAMHD1
在線閱讀:	https://doi.org/10.1002/advs.202411988
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