Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
Background: Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages. Since dNTPs are required for reverse transcription, HIV-2 and most SIVs encode a Vpx protein that pr...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Case Western Reserve University
2018-12-01
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| Colección: | Pathogens and Immunity |
| Materias: | |
| Acceso en línea: | https://paijournal.com/index.php/paijournal/article/view/263 |
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