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Disulfiram and Its Derivatives: An Immortal Phoenix of Drug Repurposing

Disulfiram (DSF) is a well-established inhibitor of aldehyde dehydrogenases (ALDHs) and an FDA-approved drug for chronic alcoholism. DSF has gained attention as a versatile scaffold for drug repurposing. Its metabolite, diethyldithiocarbamate (DDTC), mediates multiple biological effects via metal ch...

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Principais autores: Ziad Omran, Omeima Abdullah
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-01-01
Serier:Pharmaceuticals
Fag:
disulfiram
dithiocarbamate
aldehyde dehydrogenase
drug repurposing
Online adgang:https://www.mdpi.com/1424-8247/19/2/200
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