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Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Abstract Mitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and phenotypic outcomes remain elusive, par...

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Principais autores: Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2026-01-01
coleção:Advanced Science
Assuntos:
ALKBH3
demethylation editor
Mitochondrial RNA
N1‐methyladenosine
PUF
Acesso em linha:https://doi.org/10.1002/advs.202510482
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