Bifunctional Role of Fe(II)/2OG-Dependent TET Family 5-Methylcytosine Dioxygenases and ALKBH2,3 in Modified Cytosine Demethylation
Three forms of methylated cytosines are present in the eukaryotic genome: 3-methylcytosine, 4-methylcytosine and 5-methylcytosine. 3-methylcytosines create methyl lesions, which impair local DNA function and flexibility, resulting in replication and transcription error. On the other hand, 5-methylcy...
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| Formato: | Artigo |
| Idioma: | Inglês |
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MDPI AG
2022-07-01
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| Colecção: | BioChem |
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| Acesso em linha: | https://www.mdpi.com/2673-6411/2/3/12 |
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