PPM1G Inhibits Epithelial–Mesenchymal Transition in Cholangiocarcinoma by Catalyzing TET1 Dephosphorylation for Destabilization to Impair Its Targeted Demethylation of the CLDN3 Promoter

Abstract Ten–eleven translocation protein 1 (TET1) functions as an epigenetic regulatory molecule, mediating the majority of DNA demethylation, and plays a role in the development of different types of cancers by regulating the expression of proto‐oncogenes and oncogenes. Here it is found that TET1...

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Principais autores:	Wenzheng Liu, Yiyang Kuai, Da Wang, Junsheng Chen, Fei Xiong, Guanhua Wu, Qi Wang, Wenhua Huang, Yongqiang Qi, Bing Wang, Yongjun Chen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2024-12-01
Series:	Advanced Science
Assuntos:	cholangiocarcinoma demethylation dephosphorylation PPM1G TET1
Acceso en liña:	https://doi.org/10.1002/advs.202407323
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