Intranasal replicon vaccine establishes mucosal immunity and protects against H5N1 and H7N9 influenza

Abstract Seasonal and pandemic influenza viruses are continuous threats to human health, requiring rapid development of vaccines to multiple evolving viral strains. RNA vaccine technologies have the adaptability and manufacturability to facilitate pandemic preparedness but have limited flexibility i...

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Principais autores:	Matthew R. Ykema, Michael A. Davis, Darshan N. Kasal, Madeleine F. Jennewein, Ethan Lo, Jasneet Singh, Samuel Beaver, Noah Cross, Eduard Melief, Sierra Reed, Christopher Press, Devin S. Brandt, Wynton D. McClary, Raodoh Mohamath, Pauline Fusco, Julie Bakken, Corey Casper, Airn Tolnay Hartwig, Alana Gerhardt, Richard A. Bowen, Emily A. Voigt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-01-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-64829-6
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