Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau

Abstract Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzheimer’s disease. Interestingly, seasonal hibernators show extensive tau hyperphosphorylation during torpor, i.e., the hypothermic and hypometabolic state of hibernation,...

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Detalhes bibliográficos

Principais autores:	C. F. de Veij Mestdagh, M. E. Witte, W. Scheper, A. B. Smit, R. H. Henning, R. E. van Kesteren
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-06-01
coleção:	Acta Neuropathologica Communications
Assuntos:	Mouse torpor Hibernation Alzheimer’s Disease Human tau expressing mice Tau hyperphosphorylation AT8 somato-dendritic accumulation
Acesso em linha:	https://doi.org/10.1186/s40478-024-01800-4
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