Overexpression of GSK-3β in Adult Tet-OFF GSK-3β Transgenic Mice, and Not During Embryonic or Postnatal Development, Induces Tau Phosphorylation, Neurodegeneration and Learning Deficits
GSK-3β or tau-kinase I is particularly abundant in the central nervous system (CNS), playing a key role in the pathogenesis of Alzheimer’s disease (AD). Accordingly, transgenic mouse models overexpressing this kinase recapitulate some aspects of this disease, such as tau hyperphosphorylation, neuron...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Molecular Neuroscience |
| Assuntos: | |
| Acceso en liña: | https://www.frontiersin.org/article/10.3389/fnmol.2020.561470/full |
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