GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

Abstract Background Although diabetic retinopathy (DR) has long been considered as a microvascular disorder, mounting evidence suggests that diabetic retinal neurodegeneration, in particular synaptic loss and dysfunction of retinal ganglion cells (RGCs) may precede retinal microvascular changes. Key...

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Detalhes bibliográficos

Principais autores:	Huazhang Zhu, Weizhen Zhang, Yingying Zhao, Xingsheng Shu, Wencong Wang, Dandan Wang, Yangfan Yang, Zhijun He, Xiaomei Wang, Ying Ying
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-11-01
coleção:	Molecular Neurodegeneration
Assuntos:	Diabetic retinopathy Retinal neurodegeneration Retinal ganglion cells Hyperphosphorylated tau GSK3β Synaptic and mitochondrial dysfunction
Acesso em linha:	http://link.springer.com/article/10.1186/s13024-018-0295-z
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