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Prolactin enhances T regulatory cell promotion of breast cancer through the long form prolactin receptor

Previous work has shown systemic knockdown of the long form prolactin receptor (LFPRLR) in vivo markedly reduced metastasis in mouse models of breast cancer, but whether this translated to prolonged survival was unknown. Here we show that LFPRLR knockdown in the highly metastatic, immunocompetent 4T...

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Principais autores: Kuan-Hui Ethan Chen, Mrinal Ghosh, Lorena Rivera, Samuel Lin, Anil Kumar, Srividya Swaminathan, Mary Y. Lorenson, Ameae M. Walker
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-11-01
Serier:Translational Oncology
Fag:
Prolactin receptor knockdown
Prolactin
Tumor Treg recruitment
Epithelial to mesenchymal transition
TGF-β1
IL-10
Online adgang:http://www.sciencedirect.com/science/article/pii/S193652332100187X
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