Prolactin enhances T regulatory cell promotion of breast cancer through the long form prolactin receptor

Previous work has shown systemic knockdown of the long form prolactin receptor (LFPRLR) in vivo markedly reduced metastasis in mouse models of breast cancer, but whether this translated to prolonged survival was unknown. Here we show that LFPRLR knockdown in the highly metastatic, immunocompetent 4T...

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Autori principali:	Kuan-Hui Ethan Chen, Mrinal Ghosh, Lorena Rivera, Samuel Lin, Anil Kumar, Srividya Swaminathan, Mary Y. Lorenson, Ameae M. Walker
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-11-01
Serie:	Translational Oncology
Soggetti:	Prolactin receptor knockdown Prolactin Tumor Treg recruitment Epithelial to mesenchymal transition TGF-β1 IL-10
Accesso online:	http://www.sciencedirect.com/science/article/pii/S193652332100187X
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