Practical solutions for overcoming artificial disulfide scrambling in the non-reduced peptide mapping characterization of monoclonal antibodies

Non-reduced peptide mapping provides essential data for characterizing therapeutic monoclonal antibodies by isolating disulfide connections between specific cysteines. However, conventional digestive strategies used throughout the biopharmaceutical industry have been shown to cause unintentional rea...

Olles dieđut

Bibliográfalaš dieđut

Váldodahkkit:	Andrew Kleinberg, Yuan Mao, Ning Li
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Taylor & Francis Group 2024-12-01
Ráidu:	mAbs
Fáttát:	Acidic digestion cysteine alkylation disulfide scrambling non-reduced peptide mapping thiol-disulfide exchange β-elimination
Liŋkkat:	https://www.tandfonline.com/doi/10.1080/19420862.2024.2420805
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!