Practical solutions for overcoming artificial disulfide scrambling in the non-reduced peptide mapping characterization of monoclonal antibodies

Non-reduced peptide mapping provides essential data for characterizing therapeutic monoclonal antibodies by isolating disulfide connections between specific cysteines. However, conventional digestive strategies used throughout the biopharmaceutical industry have been shown to cause unintentional rea...

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Bibliografiske detaljer

Principais autores:	Andrew Kleinberg, Yuan Mao, Ning Li
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis Group 2024-12-01
Serier:	mAbs
Fag:	Acidic digestion cysteine alkylation disulfide scrambling non-reduced peptide mapping thiol-disulfide exchange β-elimination
Online adgang:	https://www.tandfonline.com/doi/10.1080/19420862.2024.2420805
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