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Understanding the Dynamics of Gene Regulatory Systems; Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms

Modern genetic analysis has shown that most polymorphisms associated with human disease are non-coding. Much of the functional information contained in the non-coding genome consists of cis-regulatory sequences (CRSs) that are required to respond to signal transduction cues that direct cell specific...

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Збережено в:
Автори: Philip Cowie, Ruth Ross, Alasdair MacKenzie
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2013-01-01
Серія:Biology
Предмети:
gene regulation
cis-regulatory variation
non-coding DNA
chromatin
signal transduction
drug response stratification
cell specificity
context dependency
ENCODE consortium
Онлайн доступ:http://www.mdpi.com/2079-7737/2/1/64
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