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Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones

Changes in the expression of the neuropeptide substance P (SP) in different populations of sensory neurones are associated with the progression of chronic inflammatory disease. Thus, understanding the genomic and cellular mechanisms driving the expression of the TAC1 gene, which encodes SP, in senso...

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Principais autores: Lynne Shanley, Scott Davidson, Marissa Lear, Anil Kumar Thotakura, Iain Joseph McEwan, Ruth A. Ross, Alasdair MacKenzie
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2010-12-01
coleção:Neurosignals
Assuntos:
Substance-P
TAC1 gene
Gene regulation
Regulatory synergy
Enhancer-promoter selectivity
MEK/ERK signalling
Comparative genomics
Sensory neurons
Capsaicin
Hyperalgesia
Acesso em linha:http://www.karger.com/Article/FullText/322010
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