Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma

Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, a known STAT3 regulator, is robustly silenced in MF tumor-stage and CTCL cells...

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Autors principals:	Lidia García-Colmenero, Jéssica González, Juan Sandoval, Yolanda Guillén, Angel Diaz-Lagares, Evelyn Andrades, Arnau Iglesias, Lara Nonell, Ramon Maria Pujol, Anna Bigas, Lluís Espinosa, Fernando Gallardo
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2020-12-01
Col·lecció:	Cells
Matèries:	cutaneous T-cell lymphoma mycosis fungoides Sézary syndrome STAT3 (signal transducer and activator of transcription-3) JAK/STAT (janus kinase/signal transducer and activator of transcription) miR-124
Accés en línia:	https://www.mdpi.com/2073-4409/9/12/2692
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