Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma

Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, a known STAT3 regulator, is robustly silenced in MF tumor-stage and CTCL cells...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Lidia García-Colmenero, Jéssica González, Juan Sandoval, Yolanda Guillén, Angel Diaz-Lagares, Evelyn Andrades, Arnau Iglesias, Lara Nonell, Ramon Maria Pujol, Anna Bigas, Lluís Espinosa, Fernando Gallardo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-12-01
coleção:	Cells
Assuntos:	cutaneous T-cell lymphoma mycosis fungoides Sézary syndrome STAT3 (signal transducer and activator of transcription-3) JAK/STAT (janus kinase/signal transducer and activator of transcription) miR-124
Acesso em linha:	https://www.mdpi.com/2073-4409/9/12/2692
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!