TRIM45 restricts influenza virus infection through modulating the chaperone-mediated autophagic degradation of viral PB2 protein.

The host defense system employs elaborate mechanisms to combat invading viruses. Here, we demonstrate that tripartite motif containing 45 (TRIM45) restricts the replication of different subtypes of influenza virus. TRIM45 interacted with and reduced the level of viral polymerase basic protein 2 (PB2...

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Autors principals:	Yihan Wang, Li Jiang, Qibing Li, Mengya Li, Wenjun Shi, Bo Wang, Guangwen Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Hualan Chen, Chengjun Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2025-10-01
Col·lecció:	PLoS Pathogens
Accés en línia:	https://doi.org/10.1371/journal.ppat.1013630
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