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Activation of CXCR3+ Tfh cells and B cells in lymph nodes during acute HIV-1 infection correlates with HIV-specific antibody development

ABSTRACT Lymph node T follicular helper (Tfh) cells and germinal center (GC) B cells are critical to generate potent antibodies but are rarely possible to study in humans. To understand how Tfh/GC B-cell interactions during acute HIV-1 infection (AHI) impact the generation of HIV-specific antibodies...

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I tiakina i:
Ngā kaituhi matua: Julie L. Mitchell, Supranee Buranapraditkun, Pierre Gantner, Hiroshi Takata, Kenneth Dietze, Kombo F. N'guessan, Justin Pollara, Junsuke Nohara, Roshell Muir, Eugene Kroon, Suteeraporn Pinyakorn, Nicha Tulmethakaan, Sopark Manasnayakorn, Suthat Chottanapund, Pattarawat Thantiworasit, Peeriya Prueksakaew, Nisakorn Ratnaratorn, Suwanna Puttamaswin, Bessara Nuntapinit, Lawrence Fox, Elias K. Haddad, Dominic Paquin-Proulx, Praphan Phanuphak, Carlo P. Sacdalan, Nittaya Phanuphak, Jintanat Ananworanich, Denise Hsu, Sandhya Vasan, Guido Ferrari, Nicolas Chomont, Lydie Trautmann
Hōputu: Artigo
Reo:Inglês
I whakaputaina: American Society for Microbiology 2025-03-01
Rangatū:Journal of Virology
Ngā marau:
human immunodeficiency virus
Tfh cells
B-cell responses
humoral immunity
lymph node
Urunga tuihono:https://journals.asm.org/doi/10.1128/jvi.01532-24
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