Comprehensive Molecular Screening by Next Generation Sequencing of Gastrointestinal Stromal Tumors (GISTs): In Silico Analysis and Classification of Rare KIT Exon 11 Mutations

ABSTRACT Introduction Gastrointestinal stromal tumors (GISTs) originate from mesenchymal precursor cells of the gastrointestinal wall and account for approximately 3% of all gastrointestinal malignancies. In adults, these tumors most commonly harbor mutually exclusive activating mutations in KIT, PD...

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Principais autores:	Maria Grazia Rodriquenz, Barbara Pasculli, Michelina Rendina, Francesco Petrizzelli, Tommaso Mazza, Antonio Petracca, Bartolomeo Augello, Michelina Coco, Teresa Balsamo, Anna Troiano, Magda Zanelli, Evaristo Maiello, Paolo Graziano, Paola Parente, Paola Parrella
格式:	Artigo
语言:	Inglês
出版:	Wiley 2025-12-01
丛编:	Cancer Medicine
主题:	gastrointestinal stromal tumors (GISTs) KIT Next Generation Sequencing (NGS) PDGFRA SDH genes structural bioinformatics
在线阅读:	https://doi.org/10.1002/cam4.71430
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