SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation

Abstract The suppressors of cytokine signaling 2 (SOCS2) inhibits growth hormone receptor (GHR) signaling by negative feedback in the regulation of metabolism. In this study, we found that GHR upregulates SOCS2 expression, whereas KIT mutations, the key driver mutations of gastrointestinal stromal t...

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主要な著者:	Liangying Zhang, Kun Xiao, Shaoting Zhang, Sien Zhao, Zimei Liu, Ming Wang, Kaiyue Qin, Yuanyuan Yu, Shujing Li, Lijun Ma, Jianmin Sun
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-02-01
シリーズ:	Scientific Reports
主題:	SOCS2 KIT GISTs Mutation Imatinib
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-89477-0
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