SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation

Abstract The suppressors of cytokine signaling 2 (SOCS2) inhibits growth hormone receptor (GHR) signaling by negative feedback in the regulation of metabolism. In this study, we found that GHR upregulates SOCS2 expression, whereas KIT mutations, the key driver mutations of gastrointestinal stromal t...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Liangying Zhang, Kun Xiao, Shaoting Zhang, Sien Zhao, Zimei Liu, Ming Wang, Kaiyue Qin, Yuanyuan Yu, Shujing Li, Lijun Ma, Jianmin Sun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-02-01
coleção:	Scientific Reports
Assuntos:	SOCS2 KIT GISTs Mutation Imatinib
Acesso em linha:	https://doi.org/10.1038/s41598-025-89477-0
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!