Transferability of polygenic risk scores for metabolic and cardiovascular traits in an underrepresented population

Abstract Polygenic risk scores (PRSs) are promising tools for genetic risk stratification, but their performance across ancestries remains uncertain. We evaluated 64 published PRSs for eight cardiometabolic traits in 4879 Thai individuals using imputed SNP-array data. Cross-sectional and six-year lo...

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Bibliografiske detaljer

Principais autores:	Phongthana Pasookhush, Apinya Surawit, Sophida Suta, Sureeporn Pumeiam, Pichanun Mongkolsucharitkul, Bonggochpass Pinsawas, Suphawan Ophakas, Yuthana Udomphorn, Sissades Tongsima, Pongsakorn Wangkumhang, Tassathorn Poonsin, Korapat Mayurasakorn
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-11-01
Serier:	npj Genomic Medicine
Online adgang:	https://doi.org/10.1038/s41525-025-00532-1
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