p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human and murine separation-of-function p53 alleles, we...

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書誌詳細

主要な著者:	Sunetra Roy, Karl-Heinz Tomaszowski, Jessica W Luzwick, Soyoung Park, Jun Li, Maureen Murphy, Katharina Schlacher
フォーマット:	Artigo
言語:	Inglês
出版事項:	eLife Sciences Publications Ltd 2018-01-01
シリーズ:	eLife
主題:	p53 genome instability replication fork restart MRE11 BRCA2 replication protection
オンライン･アクセス:	https://elifesciences.org/articles/31723
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