Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes

Abstract Fragile X syndrome (FXS) is mostly caused by a CGG triplet expansion in the fragile X mental retardation 1 gene (FMR1). Up to 60% of affected males fulfill criteria for autism spectrum disorder (ASD), making FXS the most frequent monogenetic cause of syndromic ASD. It is unknown, however, w...

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Autors principals:	Beata Stepniak, Anne Kästner, Giulia Poggi, Marina Mitjans, Martin Begemann, Annette Hartmann, Sandra Van der Auwera, Farahnaz Sananbenesi, Dilja Krueger‐Burg, Gabriela Matuszko, Cornelia Brosi, Georg Homuth, Henry Völzke, Fritz Benseler, Claudia Bagni, Utz Fischer, Alexander Dityatev, Hans‐Jörgen Grabe, Dan Rujescu, Andre Fischer, Hannelore Ehrenreich
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2015-11-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	FMR1 FMR2 FXR1 FXR2 miR‐181 PGAS
Accés en línia:	https://doi.org/10.15252/emmm.201505696
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