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The cardioprotective effects of secoisolariciresinol diglucoside (flaxseed lignan) against cafeteria diet-induced cardiac fibrosis and vascular injury in rats: an insight into apelin/AMPK/FOXO3a signaling pathways

Introduction: Fast food is a major risk factor for atherosclerosis, a leading cause of morbidity and mortality in the Western world. Apelin, the endogenous adipokine, can protect against cardiovascular disease via activating its receptor, APJ. Concurrently, secoisolariciresinol diglucoside (SDG), a...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Azza H. Abdelwahab, Amira M. Negm, Eman S. Mahmoud, Rania M. Salama, Mona F. Schaalan, Azza A. K. El-Sheikh, Basma K. Ramadan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-07-01
Schriftenreihe:Frontiers in Pharmacology
Schlagworte:
flaxseed
secoisolariciresinol diglucoside
apelin
dyslipidemia
vascular injury
cardiac fibrosis
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fphar.2023.1199294/full
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