RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming

Incomplete knowledge of the mechanisms at work continues to hamper efforts to maximize reprogramming efficiency. Here, we present a systematic genome-wide RNAi screen to determine the global regulators during the early stages of human reprogramming. Our screen identifies functional repressors and ef...

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Autors principals:	Cheng-Xu Delon Toh, Jun-Wei Chan, Zheng-Shan Chong, Hao Fei Wang, Hong Chao Guo, Sandeep Satapathy, Dongrui Ma, Germaine Yen Lin Goh, Ekta Khattar, Lin Yang, Vinay Tergaonkar, Young-Tae Chang, James J. Collins, George Q. Daley, Keng Boon Wee, Chadi A. EL Farran, Hu Li, Yoon-Pin Lim, Frederic A. Bard, Yuin-Han Loh
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2016-06-01
Col·lecció:	Cell Reports
Matèries:	human somatic cell reprogramming genome-wide siRNA screen SFRS11 reprogramming specific alternative splicing ZNF207
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124716306477
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