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RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming

Incomplete knowledge of the mechanisms at work continues to hamper efforts to maximize reprogramming efficiency. Here, we present a systematic genome-wide RNAi screen to determine the global regulators during the early stages of human reprogramming. Our screen identifies functional repressors and ef...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Cheng-Xu Delon Toh, Jun-Wei Chan, Zheng-Shan Chong, Hao Fei Wang, Hong Chao Guo, Sandeep Satapathy, Dongrui Ma, Germaine Yen Lin Goh, Ekta Khattar, Lin Yang, Vinay Tergaonkar, Young-Tae Chang, James J. Collins, George Q. Daley, Keng Boon Wee, Chadi A. EL Farran, Hu Li, Yoon-Pin Lim, Frederic A. Bard, Yuin-Han Loh
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2016-06-01
Rangatū:Cell Reports
Ngā marau:
human somatic cell reprogramming
genome-wide siRNA screen
SFRS11
reprogramming specific alternative splicing
ZNF207
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124716306477
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