Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs

The muscarinic acetylcholine receptor family is a highly sought-after target in drug and molecular imaging discovery efforts aimed at neurological disorders. Hampered by the structural similarity of the five subtypes’ orthosteric binding pockets, these efforts largely failed to deliver subtype-selec...

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Auteurs principaux:	Jonas Kilian, Marlon Millard, Marius Ozenil, Dominik Krause, Khadija Ghaderi, Wolfgang Holzer, Ernst Urban, Helmut Spreitzer, Wolfgang Wadsak, Marcus Hacker, Thierry Langer, Verena Pichler
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-05-01
Collection:	Molecules
Sujets:	muscarinic acetylcholine receptors drug development molecular docking
Accès en ligne:	https://www.mdpi.com/1420-3049/27/10/3173
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