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Short promoters in viral vectors drive selective expression in mammalian inhibitory neurons, but do not restrict activity to specific inhibitory cell-types

Short cell-type specific promoter sequences are important for targeted gene therapy and studies of brain circuitry. We report on the ability of short promoter sequences to drive fluorescent protein expression in specific types of mammalian cortical inhibitory neurons using adeno-associated virus (AA...

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Principais autores: Jason L Nathanson, Roberto Jappelli, Eric D Scheeff, Gerard Manning, Kunihiko Obata, Sydney Brenner, Edward M Callaway
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2009-11-01
Serier:Frontiers in Neural Circuits
Fag:
transcription factor
Cortex
Viral vector
Promoter
fugu
inhibitory interneuron
Online adgang:http://journal.frontiersin.org/Journal/10.3389/neuro.04.019.2009/full
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