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Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents

Two different series of fifty-two compounds, based on 3′,4′,5′-trimethoxyaniline (<b>7a–ad</b>) and variably substituted anilines (<b>8a–v</b>) at the 7-position of the 2-substituted-[1,2,4]triazolo [1,5-<i>a</i>]pyrimidine nucleus, had moderate to potent antiproliferative activity against A549, MDA...

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Principais autores: Paola Oliva, Romeo Romagnoli, Barbara Cacciari, Stefano Manfredini, Chiara Padroni, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic, Noemi Milan, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-06-01
Serier:Pharmaceutics
Fag:
antimitotic agents
structure–activity relationship
[1,2,4]triazolo [1,5-<i>a</i>]pyrimidine
antiproliferative activity
tubulin polymerization
Online adgang:https://www.mdpi.com/1999-4923/14/6/1191
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