Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents

Two different series of fifty-two compounds, based on 3′,4′,5′-trimethoxyaniline (<b>7a–ad</b>) and variably substituted anilines (<b>8a–v</b>) at the 7-position of the 2-substituted-[1,2,4]triazolo [1,5-<i>a</i>]pyrimidine nucleus, had moderate to potent antiproliferative activity against A549, MDA...

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Hlavní autoři:	Paola Oliva, Romeo Romagnoli, Barbara Cacciari, Stefano Manfredini, Chiara Padroni, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic, Noemi Milan, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-06-01
Edice:	Pharmaceutics
Témata:	antimitotic agents structure–activity relationship [1,2,4]triazolo [1,5-<i>a</i>]pyrimidine antiproliferative activity tubulin polymerization
On-line přístup:	https://www.mdpi.com/1999-4923/14/6/1191
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