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Covalent Modification of Keap1 by the Key Metabolic Cofactor Coenzyme A Under Oxidative and Metabolic Stress

Kelch-like ECH-associated protein 1 (Keap1) acts as a repressor of nuclear factor-erythroid 2-related factor 2 (Nrf2), a major transcription factor regulating cellular antioxidant response. Keap1 is the substrate adaptor subunit of the cullin 3-RING E3 ubiquitin ligase complex that specifically faci...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xuezhe Zhou, Oksana Malanchuk, Dejun Zhang, Alexander Zhyvoloup, Maria-Armineh Tossounian, Takafumi Suzuki, Masayuki Yamamoto, Valeriy Filonenko, Jerome Gouge, Ivan Gout
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2026-06-01
Schriftenreihe:Antioxidants
Schlagworte:
Keap1/Nrf2
coenzyme A
post-translational modification
CoAlation
antioxidant response
Online-Zugang:https://www.mdpi.com/2076-3921/15/6/702
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