Covalent Modification of Keap1 by the Key Metabolic Cofactor Coenzyme A Under Oxidative and Metabolic Stress

Kelch-like ECH-associated protein 1 (Keap1) acts as a repressor of nuclear factor-erythroid 2-related factor 2 (Nrf2), a major transcription factor regulating cellular antioxidant response. Keap1 is the substrate adaptor subunit of the cullin 3-RING E3 ubiquitin ligase complex that specifically faci...

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Autori principali:	Xuezhe Zhou, Oksana Malanchuk, Dejun Zhang, Alexander Zhyvoloup, Maria-Armineh Tossounian, Takafumi Suzuki, Masayuki Yamamoto, Valeriy Filonenko, Jerome Gouge, Ivan Gout
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-06-01
Serie:	Antioxidants
Soggetti:	Keap1/Nrf2 coenzyme A post-translational modification CoAlation antioxidant response
Accesso online:	https://www.mdpi.com/2076-3921/15/6/702
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