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Imaging the TGFβ type I receptor in pulmonary arterial hypertension

Abstract Transforming growth factor β (TGFβ) activity is perturbed in remodelled pulmonary vasculature of patients with pulmonary arterial hypertension (PAH), cancer, vascular diseases and developmental disorders. Inhibition of TGFβ, which signals via activin receptor-like kinase 5 (ALK5), prevents...

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Principais autores: Lonneke Rotteveel, Alex J. Poot, Esther J. M. Kooijman, Robert C. Schuit, Ingrid Schalij, Xiaoqing Sun, Kondababu Kurakula, Chris Happé, Wissam Beaino, Peter ten Dijke, Adriaan A. Lammertsma, Harm Jan Bogaard, Albert D. Windhorst
Formato: Artigo
Idioma:Inglês
Publicado: SpringerOpen 2023-03-01
Series:EJNMMI Research
Assuntos:
TGFβ type I receptor
ALK5
Positron emission tomography
Pulmonary arterial hypertension
SuHx
MCT
Acceso en liña:https://doi.org/10.1186/s13550-023-00966-7
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