Mechanistic insights into CAR-mediated repression of the HNF4α-FABP1 axis and inhibition of HepG2 cell proliferation

The constitutive androstane receptor (CAR) modulates the transcription of numerous genes involving drug metabolism, energy homeostasis, and cell proliferation. While rodent studies suggest an oncogenic role for murine CAR in liver cancer development, emerging evidence indicates that human CAR (hCAR)...

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Hlavní autoři:	Zhihui Li, Linhao Li, Ritika Kurian, Jean-Pierre Raufman, Hongbing Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-05-01
Edice:	Pharmacological Research
Témata:	CAR FABP1 HNF4α Gene regulation Hepatoma cell proliferation
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1043661826000861
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