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Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures

Abstract Background Xenobiotic exposures can extensively influence the expression and alternative splicing of drug-metabolizing enzymes, including cytochromes P450 (CYPs), though their transcriptome-wide impact on splicing remains underexplored. This study used a well-characterized splicing event in...

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Autors principals: Andrew J. Annalora, Jacki L. Coburn, Antony Jozic, Patrick L. Iversen, Craig B. Marcus
Format: Artigo
Idioma:Inglês
Publicat: BMC 2024-11-01
Col·lecció:Human Genomics
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Accés en línia:https://doi.org/10.1186/s40246-024-00694-6
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